Lois Goglia originally painted in traditional genres: portraiture, still lifes, and landscapes. In 1982, while enrolled in a graduate program at Wesleyan University, Goglia participated in a class that visited New York City galleries and museums, which exhibited contemporary art. The artwork Goglia looked at convinced her that her recent paintings, though competent, did not speak to issues of the late twentieth century. Goglia searched for a way of making art that was pertinent to the times. She found her inspiration at a veterinary hospital.

While sitting in the treatment room, Goglia's eyes fixated on an animal X-ray mounted on a light box hanging on a wall across the room. She found the animal image beautiful, despite its associations with illness. Its value contrasts, textures, and anatomical shapes made the X-ray visually compelling. X-rays provided a thematic concept that she is still investigating today: the relationship between art and science.

In Goglia's first series that utilized X-rays in her art, she incorporated animal X-rays, bandages, and medical tapes with traditional art supplies, such as canvas, India inks, suturing materials, and oilsticks to create Healing Figure Constructions.

Continuing her interest in the relationship between art and science, Goglia subsequently created a Healing Figure Sculpture Series as well as an installation titled, Galapagos Fantasy Island: A Natural Selection. Although the two series did not utilize X-ray radiographs, Goglia never lost sight of her idea to use illuminated X-ray films in a collage format.

The GENESIS series was inspired by a gift of DNA sequencing gels and petri dish X-ray radiographs furnished by a Yale University Medical School researcher. This is a series of eighteen collages created from X-ray films. The images are wall mounted, illuminated on light boxes. They chronicle the beginning of life from the growth of individual cells in petri dishes to the development of a full-term fetus. DNA sequencing gels, animal and human X-rays, a mammogram, as well as fetal ultrasound radiographs are incorporated into this work.

GENESIS was exhibited for the first time in February 2003 at the Housatonic Museum, Bridgeport, Connecticut. It was subsequently exhibited at the Peabody Museum, Yale University, New Haven, Connecticut in conjunction with the fiftieth anniversary of Watson and Crick's discovery of the double helix structure of DNA. A selection of these images was then exhibited at the Tang Museum, Skidmore College, Saratoga Springs, New York and the Greene Gallery at Yale University in conjunction with the New Haven Festival of Arts and Ideas.

INSIGHT, a series of giclee prints of X-ray collages, is Goglia's latest body of artwork. The prints of X-ray collages were digitally photographed, computer modified, then printed. In 2006, the INSIGHT prints won a highly competitive international exhibition at the New York Hall of Science. This competition was sponsored by Arts Science Collaboration, Inc. The prints were also exhibited in 2007, as the result of winning a national competion in conjunction with the New York Academy of Science's syposium on Science and the Arts.

The next step in Goglia's investigation of the X-ray as an art form is a series titled X-RAYS: IN LIVING COLOR. In this series Goglia has added vibrant colors to some prints from the INSIGHT Series and to some new ones.

Goglia has also had solo exhibitions at the Paul Mellon Art Center, Choate Rosemary Hall, Wallingford, CT; The Zilkha Gallery, Wesleyan University, Middletown, CT; The University of Massachusetts Medical School Gallery, Worcester, MA; The Yale Medical School Gallery, New Haven, CT; The University of Pennsylvania Gallery, Philadelphia, PA; The University of New Haven Gallery, West Haven, CT. A selected list of group exhibitions includes: The Butler Museum, Warren, OH; The New Britain Museum, New Britain, CT; The Mattatuck Museum, Waterbury, CT; The Silvermine Gallery, New Canaan, CT; The Alexey Von Schippe Museum, Groton, CT.

Goglia has lectured at universities including Yale University Medical School and Southern Connecticut State College, as well as to local civic groups. Goglia wrote reviews for Art New England for five years.

Lois Goglia lives in Cheshire, Connecticut. She is married and has two sons.